TY - JOUR
T1 - Tumor-Associated-Macrophage-Membrane-Coated Nanoparticles for Improved Photodynamic Immunotherapy
AU - Chen, Cailing
AU - Song, Meiyu
AU - Du, Yangyang
AU - Yu, Ying
AU - Li, Chunguang
AU - Han, Yu
AU - Yan, Fei
AU - Shi, Zhan
AU - Feng, Shouhua
N1 - KAUST Repository Item: Exported on 2021-06-18
Acknowledgements: This work was supported by the National Natural Science Foundation of China (NSFC; nos. 81870117, 91959201, 21771077, 21771084, and 21621001), the National Key Research and Development Program of China (no. 2016YFB0701100), the 111 project (no. B17020), and the Jilin Province Science and Technology Development Plan (20190201252JC). The authors also gratefully acknowledge the financial support by Program for JLU Science and Technology Innovative Research Team (JLUSTIRT).
PY - 2021/6/16
Y1 - 2021/6/16
N2 - Cell-membrane-coated nanoparticles have emerged as a promising antitumor therapeutic strategy. However, the immunologic mechanism remains elusive, and there are still crucial issues to be addressed including tumor-homing capacity, immune incompatibility,
and immunogenicity. Here, we reported a tumor-associated macrophage membrane (TAMM) derived from the primary tumor with
unique antigen-homing affinity capacity and immune compatibility. TAMM could deplete the CSF1 secreted by tumor cells in the tumor
microenvironment (TME), blocking the interaction between TAM and cancer cells. Especially, after coating TAMM to upconversion
nanoparticle with conjugated photosensitizer (NPR@TAMM), NPR@TAMM-mediated photodynamic immunotherapy switched
the activation of macrophages from an immunosuppressive M2-like phenotype to a more inflammatory M1-like state, induced immunogenic cell death, and consequently enhanced the antitumor immunity efficiency via activation of antigen-presenting cells to stimulate the production of tumor-specific effector T cells in metastatic tumors. This TAM-membrane-based photodynamic immunotherapy approach offers a new strategy for personalized tumor therapy.
AB - Cell-membrane-coated nanoparticles have emerged as a promising antitumor therapeutic strategy. However, the immunologic mechanism remains elusive, and there are still crucial issues to be addressed including tumor-homing capacity, immune incompatibility,
and immunogenicity. Here, we reported a tumor-associated macrophage membrane (TAMM) derived from the primary tumor with
unique antigen-homing affinity capacity and immune compatibility. TAMM could deplete the CSF1 secreted by tumor cells in the tumor
microenvironment (TME), blocking the interaction between TAM and cancer cells. Especially, after coating TAMM to upconversion
nanoparticle with conjugated photosensitizer (NPR@TAMM), NPR@TAMM-mediated photodynamic immunotherapy switched
the activation of macrophages from an immunosuppressive M2-like phenotype to a more inflammatory M1-like state, induced immunogenic cell death, and consequently enhanced the antitumor immunity efficiency via activation of antigen-presenting cells to stimulate the production of tumor-specific effector T cells in metastatic tumors. This TAM-membrane-based photodynamic immunotherapy approach offers a new strategy for personalized tumor therapy.
UR - http://hdl.handle.net/10754/669683
UR - https://pubs.acs.org/doi/10.1021/acs.nanolett.1c00818
U2 - 10.1021/acs.nanolett.1c00818
DO - 10.1021/acs.nanolett.1c00818
M3 - Article
C2 - 34133181
SN - 1530-6984
JO - Nano Letters
JF - Nano Letters
ER -
