Ultra low concentrated molecular detection using super hydrophobic surface based biophotonic devices

F. Gentile*, G. Das, M. L. Coluccio, F. Mecarini, A. Accardo, Luca Tirinato, R. Tallerico, G. Cojoc, C. Liberale, P. Candeloro, P. Decuzzi, F. De Angelis, E. Di Fabrizio

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

74 Scopus citations


Micro and nano-patterned devices were fabricated which disclose the possibility of concentrating, localizing, detecting and thus analyzing with unprecedented accuracy few molecules (at the limit a single molecule) of biological and medical interest. Important applications are envisioned where proteins poorly concentrated in blood are detected thus (early) revealing the appearance of diseases. The major advance of the paper is that it combines micro/nano-fabrication and spectroscopical nano-optics based techniques to study and individualize the biomolecules at study. Super hydrophobic surface would concentrate the diluted solution into a small area whereas spectroscopical nano-optics techniques would gather the molecular/chemical information of the residual solute. Fluorescence and SERS techniques were used to analyze Rhodamine molecules initially highly diluted (10-18 M).

Original languageEnglish (US)
Pages (from-to)798-801
Number of pages4
JournalMicroelectronic Engineering
Issue number5-8
StatePublished - May 2010
Externally publishedYes


  • Biophotonics and plasmonics
  • Cancer
  • Early detection
  • Super hydrophobic surfaces

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Condensed Matter Physics
  • Surfaces, Coatings and Films
  • Electrical and Electronic Engineering


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