Ultra low concentrated molecular detection using super hydrophobic surface based biophotonic devices

F. Gentile; G. Das; M. L. Coluccio; F. Mecarini; A. Accardo; Luca Tirinato; R. Tallerico; G. Cojoc; C. Liberale; P. Candeloro; P. Decuzzi; F. De Angelis; E. Di Fabrizio

doi:10.1016/j.mee.2009.11.083

Ultra low concentrated molecular detection using super hydrophobic surface based biophotonic devices

F. Gentile^*, G. Das, M. L. Coluccio, F. Mecarini, A. Accardo, Luca Tirinato, R. Tallerico, G. Cojoc, C. Liberale, P. Candeloro, P. Decuzzi, F. De Angelis, E. Di Fabrizio

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

74 Scopus citations

Abstract

Micro and nano-patterned devices were fabricated which disclose the possibility of concentrating, localizing, detecting and thus analyzing with unprecedented accuracy few molecules (at the limit a single molecule) of biological and medical interest. Important applications are envisioned where proteins poorly concentrated in blood are detected thus (early) revealing the appearance of diseases. The major advance of the paper is that it combines micro/nano-fabrication and spectroscopical nano-optics based techniques to study and individualize the biomolecules at study. Super hydrophobic surface would concentrate the diluted solution into a small area whereas spectroscopical nano-optics techniques would gather the molecular/chemical information of the residual solute. Fluorescence and SERS techniques were used to analyze Rhodamine molecules initially highly diluted (10^-18 M).

Original language	English (US)
Pages (from-to)	798-801
Number of pages	4
Journal	Microelectronic Engineering
Volume	87
Issue number	5-8
DOIs	https://doi.org/10.1016/j.mee.2009.11.083
State	Published - May 2010
Externally published	Yes

Keywords

Biophotonics and plasmonics
Cancer
Early detection
Super hydrophobic surfaces

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics
Condensed Matter Physics
Surfaces, Coatings and Films
Electrical and Electronic Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.mee.2009.11.083

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Gentile, F., Das, G., Coluccio, M. L., Mecarini, F., Accardo, A., Tirinato, L., Tallerico, R., Cojoc, G., Liberale, C., Candeloro, P., Decuzzi, P., De Angelis, F., & Di Fabrizio, E. (2010). Ultra low concentrated molecular detection using super hydrophobic surface based biophotonic devices. Microelectronic Engineering, 87(5-8), 798-801. https://doi.org/10.1016/j.mee.2009.11.083

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title = "Ultra low concentrated molecular detection using super hydrophobic surface based biophotonic devices",

abstract = "Micro and nano-patterned devices were fabricated which disclose the possibility of concentrating, localizing, detecting and thus analyzing with unprecedented accuracy few molecules (at the limit a single molecule) of biological and medical interest. Important applications are envisioned where proteins poorly concentrated in blood are detected thus (early) revealing the appearance of diseases. The major advance of the paper is that it combines micro/nano-fabrication and spectroscopical nano-optics based techniques to study and individualize the biomolecules at study. Super hydrophobic surface would concentrate the diluted solution into a small area whereas spectroscopical nano-optics techniques would gather the molecular/chemical information of the residual solute. Fluorescence and SERS techniques were used to analyze Rhodamine molecules initially highly diluted (10-18 M).",

keywords = "Biophotonics and plasmonics, Cancer, Early detection, Super hydrophobic surfaces",

author = "F. Gentile and G. Das and Coluccio, {M. L.} and F. Mecarini and A. Accardo and Luca Tirinato and R. Tallerico and G. Cojoc and C. Liberale and P. Candeloro and P. Decuzzi and {De Angelis}, F. and {Di Fabrizio}, E.",

year = "2010",

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doi = "10.1016/j.mee.2009.11.083",

language = "English (US)",

volume = "87",

pages = "798--801",

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Gentile, F, Das, G, Coluccio, ML, Mecarini, F, Accardo, A, Tirinato, L, Tallerico, R, Cojoc, G, Liberale, C, Candeloro, P, Decuzzi, P, De Angelis, F & Di Fabrizio, E 2010, 'Ultra low concentrated molecular detection using super hydrophobic surface based biophotonic devices', Microelectronic Engineering, vol. 87, no. 5-8, pp. 798-801. https://doi.org/10.1016/j.mee.2009.11.083

TY - JOUR

T1 - Ultra low concentrated molecular detection using super hydrophobic surface based biophotonic devices

AU - Gentile, F.

AU - Das, G.

AU - Coluccio, M. L.

AU - Mecarini, F.

AU - Accardo, A.

AU - Tirinato, Luca

AU - Tallerico, R.

AU - Cojoc, G.

AU - Liberale, C.

AU - Candeloro, P.

AU - Decuzzi, P.

AU - De Angelis, F.

AU - Di Fabrizio, E.

PY - 2010/5

Y1 - 2010/5

N2 - Micro and nano-patterned devices were fabricated which disclose the possibility of concentrating, localizing, detecting and thus analyzing with unprecedented accuracy few molecules (at the limit a single molecule) of biological and medical interest. Important applications are envisioned where proteins poorly concentrated in blood are detected thus (early) revealing the appearance of diseases. The major advance of the paper is that it combines micro/nano-fabrication and spectroscopical nano-optics based techniques to study and individualize the biomolecules at study. Super hydrophobic surface would concentrate the diluted solution into a small area whereas spectroscopical nano-optics techniques would gather the molecular/chemical information of the residual solute. Fluorescence and SERS techniques were used to analyze Rhodamine molecules initially highly diluted (10-18 M).

AB - Micro and nano-patterned devices were fabricated which disclose the possibility of concentrating, localizing, detecting and thus analyzing with unprecedented accuracy few molecules (at the limit a single molecule) of biological and medical interest. Important applications are envisioned where proteins poorly concentrated in blood are detected thus (early) revealing the appearance of diseases. The major advance of the paper is that it combines micro/nano-fabrication and spectroscopical nano-optics based techniques to study and individualize the biomolecules at study. Super hydrophobic surface would concentrate the diluted solution into a small area whereas spectroscopical nano-optics techniques would gather the molecular/chemical information of the residual solute. Fluorescence and SERS techniques were used to analyze Rhodamine molecules initially highly diluted (10-18 M).

KW - Biophotonics and plasmonics

KW - Cancer

KW - Early detection

KW - Super hydrophobic surfaces

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DO - 10.1016/j.mee.2009.11.083

M3 - Article

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VL - 87

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JO - Microelectronic Engineering

JF - Microelectronic Engineering

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ER -

Ultra low concentrated molecular detection using super hydrophobic surface based biophotonic devices

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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