Abstract
Excited-state palladium catalysis is an efficient process for the alkylation of diverse organic compounds via the generation of alkyl radicals from alkyl bromides and iodides. However, the generation of alkyl radicals from more stable alkyl chlorides remains challenging. Herein, we demonstrate the excited-state palladium-catalyzed synthesis of oxindoles and isoquinolinediones via alkylation/annulation reaction by overcoming inherent limitations associated with unactivated C(sp3)-Cl bond activation at room temperature.
Original language | English (US) |
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Journal | Organic Letters |
DOIs | |
State | Published - Aug 25 2021 |
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Physical and Theoretical Chemistry