Vaccination strategies for tuberculosis

Abhinav Mehta; Rajeev K. Tyagi; Amit Goyal; Kapil Khatri; Prem N. Gupta; S. P. Vyas

Vaccination strategies for tuberculosis

Abhinav Mehta, Rajeev K. Tyagi, Amit Goyal, Kapil Khatri, Prem N. Gupta, S. P. Vyas

Research output: Contribution to journal › Article › peer-review

Abstract

The widespread plague of tuberculosis (TB) has continued despite the availability of licensed TB vaccine (BCG) and directly observed chemotherapy (DOTS) programmes. Also, emergence of multi-drug resistant strains of Mycobacterium tuberculosis presents serious challenges for the DOTS strategy. Today, TB still remains a deadly disease and leading infectious killer of youth and adults. Clearly, there is a need for an improved TB vaccine. Various efforts have been made in this direction, and a heterologous prime-boost regimen probably represents the best hope for an improved vaccine regimen to prevent TB. The first generation of new vaccines might also complement drug-treatment regimens and be effective against reactivation of TB from the latent state, which would significantly enhance their usefulness.

Original language	English (US)
Pages (from-to)	1501-1505
Number of pages	5
Journal	Current Science
Volume	93
Issue number	11
State	Published - Dec 10 2007
Externally published	Yes

ASJC Scopus subject areas

General

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Vaccination strategies for tuberculosis",

abstract = "The widespread plague of tuberculosis (TB) has continued despite the availability of licensed TB vaccine (BCG) and directly observed chemotherapy (DOTS) programmes. Also, emergence of multi-drug resistant strains of Mycobacterium tuberculosis presents serious challenges for the DOTS strategy. Today, TB still remains a deadly disease and leading infectious killer of youth and adults. Clearly, there is a need for an improved TB vaccine. Various efforts have been made in this direction, and a heterologous prime-boost regimen probably represents the best hope for an improved vaccine regimen to prevent TB. The first generation of new vaccines might also complement drug-treatment regimens and be effective against reactivation of TB from the latent state, which would significantly enhance their usefulness.",

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AU - Mehta, Abhinav

AU - Tyagi, Rajeev K.

AU - Goyal, Amit

AU - Khatri, Kapil

AU - Gupta, Prem N.

AU - Vyas, S. P.

N1 - Generated from Scopus record by KAUST IRTS on 2023-10-12

PY - 2007/12/10

Y1 - 2007/12/10

N2 - The widespread plague of tuberculosis (TB) has continued despite the availability of licensed TB vaccine (BCG) and directly observed chemotherapy (DOTS) programmes. Also, emergence of multi-drug resistant strains of Mycobacterium tuberculosis presents serious challenges for the DOTS strategy. Today, TB still remains a deadly disease and leading infectious killer of youth and adults. Clearly, there is a need for an improved TB vaccine. Various efforts have been made in this direction, and a heterologous prime-boost regimen probably represents the best hope for an improved vaccine regimen to prevent TB. The first generation of new vaccines might also complement drug-treatment regimens and be effective against reactivation of TB from the latent state, which would significantly enhance their usefulness.

AB - The widespread plague of tuberculosis (TB) has continued despite the availability of licensed TB vaccine (BCG) and directly observed chemotherapy (DOTS) programmes. Also, emergence of multi-drug resistant strains of Mycobacterium tuberculosis presents serious challenges for the DOTS strategy. Today, TB still remains a deadly disease and leading infectious killer of youth and adults. Clearly, there is a need for an improved TB vaccine. Various efforts have been made in this direction, and a heterologous prime-boost regimen probably represents the best hope for an improved vaccine regimen to prevent TB. The first generation of new vaccines might also complement drug-treatment regimens and be effective against reactivation of TB from the latent state, which would significantly enhance their usefulness.

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M3 - Article

SN - 0011-3891

VL - 93

SP - 1501

EP - 1505

JO - Current Science

JF - Current Science

IS - 11

ER -

Vaccination strategies for tuberculosis

Abstract

ASJC Scopus subject areas

UN SDGs

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