VIP- and glucagon-induced formation of cyclic AMP in intact retinae in vitro

Michel Schorderet; Jean Yves Sovilla; Pierre J. Magistretti

doi:10.1016/0014-2999(81)90395-2

VIP- and glucagon-induced formation of cyclic AMP in intact retinae in vitro

Michel Schorderet^*, Jean Yves Sovilla, Pierre J. Magistretti

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

VIP, glucagon or several other neuropeptides were applied to intact retinae in vitro. VIP was found to be a very potent stimulator of cyclic AMP production in rabbit retina, whereas glucagon was efficient in pigeon retina. Attempts to modify the VIP-induced formation of cyclic AMP by somatostatin or dopamine-related drugs (neuroleptics) were not successful. These biochemical data may be correlated to some extent with the recent immuno-histochemical localisation of VIP and glucagon in mammalian or avian retinae.

Original language	English (US)
Pages (from-to)	131-133
Number of pages	3
Journal	European Journal of Pharmacology
Volume	71
Issue number	1
DOIs	https://doi.org/10.1016/0014-2999(81)90395-2
State	Published - Apr 24 1981
Externally published	Yes

Keywords

Cyclic AMP
Glucagon
Retina
VIP

ASJC Scopus subject areas

Pharmacology

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10.1016/0014-2999(81)90395-2

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title = "VIP- and glucagon-induced formation of cyclic AMP in intact retinae in vitro",

abstract = "VIP, glucagon or several other neuropeptides were applied to intact retinae in vitro. VIP was found to be a very potent stimulator of cyclic AMP production in rabbit retina, whereas glucagon was efficient in pigeon retina. Attempts to modify the VIP-induced formation of cyclic AMP by somatostatin or dopamine-related drugs (neuroleptics) were not successful. These biochemical data may be correlated to some extent with the recent immuno-histochemical localisation of VIP and glucagon in mammalian or avian retinae.",

keywords = "Cyclic AMP, Glucagon, Retina, VIP",

author = "Michel Schorderet and Sovilla, {Jean Yves} and Magistretti, {Pierre J.}",

year = "1981",

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AU - Schorderet, Michel

AU - Sovilla, Jean Yves

AU - Magistretti, Pierre J.

PY - 1981/4/24

Y1 - 1981/4/24

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AB - VIP, glucagon or several other neuropeptides were applied to intact retinae in vitro. VIP was found to be a very potent stimulator of cyclic AMP production in rabbit retina, whereas glucagon was efficient in pigeon retina. Attempts to modify the VIP-induced formation of cyclic AMP by somatostatin or dopamine-related drugs (neuroleptics) were not successful. These biochemical data may be correlated to some extent with the recent immuno-histochemical localisation of VIP and glucagon in mammalian or avian retinae.

KW - Cyclic AMP

KW - Glucagon

KW - Retina

KW - VIP

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VIP- and glucagon-induced formation of cyclic AMP in intact retinae in vitro

Abstract

Keywords

ASJC Scopus subject areas

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