Visible light photoredox-catalyzed multicomponent reactions

Magnus Rueping; Carlos Vila

doi:10.1021/ol400317v

Visible light photoredox-catalyzed multicomponent reactions

Magnus Rueping^*, Carlos Vila

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

139 Scopus citations

Abstract

Oxidative three-component reactions for the direct synthesis of α-amino amides and imides from tertiary amines have been developed. These reactions involve the functionalization of C(sp³)-H bonds adjacent to nitrogen atoms via mild aerobic oxidation using visible light photoredox catalysis. The protocols are applicable to a wide range of amines and isocyanides, as well as water and carboxylic acids, providing straightforward access to a variety of highly functionalized α-amino amides and imides.

Original language	English (US)
Pages (from-to)	2092-2095
Number of pages	4
Journal	Organic Letters
Volume	15
Issue number	9
DOIs	https://doi.org/10.1021/ol400317v
State	Published - May 3 2013
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol400317v

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title = "Visible light photoredox-catalyzed multicomponent reactions",

abstract = "Oxidative three-component reactions for the direct synthesis of α-amino amides and imides from tertiary amines have been developed. These reactions involve the functionalization of C(sp3)-H bonds adjacent to nitrogen atoms via mild aerobic oxidation using visible light photoredox catalysis. The protocols are applicable to a wide range of amines and isocyanides, as well as water and carboxylic acids, providing straightforward access to a variety of highly functionalized α-amino amides and imides.",

author = "Magnus Rueping and Carlos Vila",

year = "2013",

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doi = "10.1021/ol400317v",

language = "English (US)",

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journal = "Organic Letters",

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AU - Vila, Carlos

PY - 2013/5/3

Y1 - 2013/5/3

N2 - Oxidative three-component reactions for the direct synthesis of α-amino amides and imides from tertiary amines have been developed. These reactions involve the functionalization of C(sp3)-H bonds adjacent to nitrogen atoms via mild aerobic oxidation using visible light photoredox catalysis. The protocols are applicable to a wide range of amines and isocyanides, as well as water and carboxylic acids, providing straightforward access to a variety of highly functionalized α-amino amides and imides.

AB - Oxidative three-component reactions for the direct synthesis of α-amino amides and imides from tertiary amines have been developed. These reactions involve the functionalization of C(sp3)-H bonds adjacent to nitrogen atoms via mild aerobic oxidation using visible light photoredox catalysis. The protocols are applicable to a wide range of amines and isocyanides, as well as water and carboxylic acids, providing straightforward access to a variety of highly functionalized α-amino amides and imides.

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U2 - 10.1021/ol400317v

DO - 10.1021/ol400317v

M3 - Article

C2 - 23586924

AN - SCOPUS:84877102165

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SP - 2092

EP - 2095

JO - Organic Letters

JF - Organic Letters

IS - 9

ER -

Visible light photoredox-catalyzed multicomponent reactions

Abstract

ASJC Scopus subject areas

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