Well-defined linear multiblock and branched polypeptides by linking chemistry

Thrasyvoulos Aliferis, Hermis Iatrou, Nikos Hadjichristidis*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

46 Scopus citations


The synthesis of linear multiblock copolypeptides along with three-arm star homo- and copolypeptides was investigated. The precursors along with the final copolypeptides were characterized by membrane osmometry and size exclusion chromatography (SEC) featuring a two-angle laser scattering (TALLS) detector. In both methods, the measurements were performed at 60°C and the solvent was a 0.1N LiBr solution in N,N'-dimethylformamide (DMF). It was concluded that the livingness of the polypeptides under high-vacuum (HV) conditions can be preserved indefinitely and this allows the use of coupling chemistry for the synthesis of homo- and copolypeptides with a wide variety of macromolecular architectures.

Original languageEnglish (US)
Pages (from-to)4670-4673
Number of pages4
JournalJournal of Polymer Science, Part A: Polymer Chemistry
Issue number19
StatePublished - Oct 1 2005
Externally publishedYes


  • Block copolypeptides
  • Light scattering
  • Living polymerization
  • Ring-opening polymerization
  • Star copolypeptides

ASJC Scopus subject areas

  • Polymers and Plastics
  • Organic Chemistry
  • Materials Chemistry


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