Well-defined linear multiblock and branched polypeptides by linking chemistry

Thrasyvoulos Aliferis; Hermis Iatrou; Nikos Hadjichristidis

doi:10.1002/pola.20926

Well-defined linear multiblock and branched polypeptides by linking chemistry

Thrasyvoulos Aliferis, Hermis Iatrou, Nikos Hadjichristidis^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

47 Scopus citations

Abstract

The synthesis of linear multiblock copolypeptides along with three-arm star homo- and copolypeptides was investigated. The precursors along with the final copolypeptides were characterized by membrane osmometry and size exclusion chromatography (SEC) featuring a two-angle laser scattering (TALLS) detector. In both methods, the measurements were performed at 60°C and the solvent was a 0.1N LiBr solution in N,N'-dimethylformamide (DMF). It was concluded that the livingness of the polypeptides under high-vacuum (HV) conditions can be preserved indefinitely and this allows the use of coupling chemistry for the synthesis of homo- and copolypeptides with a wide variety of macromolecular architectures.

Original language	English (US)
Pages (from-to)	4670-4673
Number of pages	4
Journal	Journal of Polymer Science, Part A: Polymer Chemistry
Volume	43
Issue number	19
DOIs	https://doi.org/10.1002/pola.20926
State	Published - Oct 1 2005
Externally published	Yes

Keywords

Block copolypeptides
Light scattering
Living polymerization
Ring-opening polymerization
Star copolypeptides

ASJC Scopus subject areas

Polymers and Plastics
Organic Chemistry
Materials Chemistry

Access to Document

10.1002/pola.20926

Cite this

@article{f4c687e059544ec4b58625834fbab3b5,

title = "Well-defined linear multiblock and branched polypeptides by linking chemistry",

abstract = "The synthesis of linear multiblock copolypeptides along with three-arm star homo- and copolypeptides was investigated. The precursors along with the final copolypeptides were characterized by membrane osmometry and size exclusion chromatography (SEC) featuring a two-angle laser scattering (TALLS) detector. In both methods, the measurements were performed at 60°C and the solvent was a 0.1N LiBr solution in N,N'-dimethylformamide (DMF). It was concluded that the livingness of the polypeptides under high-vacuum (HV) conditions can be preserved indefinitely and this allows the use of coupling chemistry for the synthesis of homo- and copolypeptides with a wide variety of macromolecular architectures.",

keywords = "Block copolypeptides, Light scattering, Living polymerization, Ring-opening polymerization, Star copolypeptides",

author = "Thrasyvoulos Aliferis and Hermis Iatrou and Nikos Hadjichristidis",

year = "2005",

month = oct,

day = "1",

doi = "10.1002/pola.20926",

language = "English (US)",

volume = "43",

pages = "4670--4673",

journal = "Journal of Polymer Science, Part A: Polymer Chemistry",

issn = "0887-624X",

publisher = "John Wiley & Sons Inc.",

number = "19",

}

TY - JOUR

T1 - Well-defined linear multiblock and branched polypeptides by linking chemistry

AU - Aliferis, Thrasyvoulos

AU - Iatrou, Hermis

AU - Hadjichristidis, Nikos

PY - 2005/10/1

Y1 - 2005/10/1

N2 - The synthesis of linear multiblock copolypeptides along with three-arm star homo- and copolypeptides was investigated. The precursors along with the final copolypeptides were characterized by membrane osmometry and size exclusion chromatography (SEC) featuring a two-angle laser scattering (TALLS) detector. In both methods, the measurements were performed at 60°C and the solvent was a 0.1N LiBr solution in N,N'-dimethylformamide (DMF). It was concluded that the livingness of the polypeptides under high-vacuum (HV) conditions can be preserved indefinitely and this allows the use of coupling chemistry for the synthesis of homo- and copolypeptides with a wide variety of macromolecular architectures.

AB - The synthesis of linear multiblock copolypeptides along with three-arm star homo- and copolypeptides was investigated. The precursors along with the final copolypeptides were characterized by membrane osmometry and size exclusion chromatography (SEC) featuring a two-angle laser scattering (TALLS) detector. In both methods, the measurements were performed at 60°C and the solvent was a 0.1N LiBr solution in N,N'-dimethylformamide (DMF). It was concluded that the livingness of the polypeptides under high-vacuum (HV) conditions can be preserved indefinitely and this allows the use of coupling chemistry for the synthesis of homo- and copolypeptides with a wide variety of macromolecular architectures.

KW - Block copolypeptides

KW - Light scattering

KW - Living polymerization

KW - Ring-opening polymerization

KW - Star copolypeptides

UR - http://www.scopus.com/inward/record.url?scp=27744534214&partnerID=8YFLogxK

U2 - 10.1002/pola.20926

DO - 10.1002/pola.20926

M3 - Review article

AN - SCOPUS:27744534214

SN - 0887-624X

VL - 43

SP - 4670

EP - 4673

JO - Journal of Polymer Science, Part A: Polymer Chemistry

JF - Journal of Polymer Science, Part A: Polymer Chemistry

IS - 19

ER -

Well-defined linear multiblock and branched polypeptides by linking chemistry

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this