TY - JOUR
T1 - “What Doesn’t Kill You Makes You Stronger”: Future Applications of Amyloid Aggregates in Biomedicine
AU - Abdelrahman, Sherin
AU - Alghrably, Mawadda
AU - Lachowicz, Joanna Izabela
AU - Emwas, Abdul-Hamid M.
AU - Hauser, Charlotte
AU - Jaremko, Mariusz
N1 - KAUST Repository Item: Exported on 2020-11-13
Acknowledgements: M.J., and M.A. would like to thank the King Abdullah University of Science and Technology (KAUST) for the financial support.
PY - 2020/11/12
Y1 - 2020/11/12
N2 - Amyloid proteins are linked to the pathogenesis of several diseases including Alzheimer’s disease, but at the same time a range of functional amyloids are physiologically important in humans. Although the disease pathogenies have been associated with protein aggregation, the mechanisms and factors that lead to protein aggregation are not completely understood. Paradoxically, unique characteristics of amyloids provide new opportunities for engineering innovative materials with biomedical applications. In this review, we discuss not only outstanding advances in biomedical applications of amyloid peptides, but also the mechanism of amyloid aggregation, factors affecting the process, and core sequences driving the aggregation. We aim with this review to provide a useful manual for those who engineer amyloids for innovative medicine solutions.
AB - Amyloid proteins are linked to the pathogenesis of several diseases including Alzheimer’s disease, but at the same time a range of functional amyloids are physiologically important in humans. Although the disease pathogenies have been associated with protein aggregation, the mechanisms and factors that lead to protein aggregation are not completely understood. Paradoxically, unique characteristics of amyloids provide new opportunities for engineering innovative materials with biomedical applications. In this review, we discuss not only outstanding advances in biomedical applications of amyloid peptides, but also the mechanism of amyloid aggregation, factors affecting the process, and core sequences driving the aggregation. We aim with this review to provide a useful manual for those who engineer amyloids for innovative medicine solutions.
UR - http://hdl.handle.net/10754/665915
UR - https://www.mdpi.com/1420-3049/25/22/5245
U2 - 10.3390/molecules25225245
DO - 10.3390/molecules25225245
M3 - Article
C2 - 33187056
SN - 1420-3049
VL - 25
SP - 5245
JO - Molecules
JF - Molecules
IS - 22
ER -