TY - JOUR
T1 - Why has reversal of the actin-myosin cross-bridge cycle not been observed experimentally?
AU - Loiselle, D. S.
AU - Tran, K.
AU - Crampin, E. J.
AU - Curtin, N. A.
N1 - KAUST Repository Item: Exported on 2020-10-01
Acknowledged KAUST grant number(s): KUK-C1-013-04
Acknowledgements: This work was supported by Grant UOA0607 from the Royal Society of New Zealand Marsden Fund. This publication is based on work (E.J. Crampin) supported in part by Award No KUK-C1-013-04, made by King Abdullah Univ. of Science and Technology (KAUST).
This publication acknowledges KAUST support, but has no KAUST affiliated authors.
PY - 2010/2/5
Y1 - 2010/2/5
N2 - We trace the history of attempts to determine whether the experimentally observed diminution of metabolic energy expenditure when muscles lengthen during active contraction is consistent with reversibility of biochemical reactions and, in particular, with the regeneration of ATP. We note that this scientific endeavor has something of a parallel flavor to it, with both early and more recent experiments exploiting both isolated muscle preparations and exercising human subjects. In tracing this history from the late 19th century to the present, it becomes clear that energy can be (at least transiently) stored in a muscle undergoing an eccentric contraction but that this is unlikely to be due to the regeneration of ATP. A recently developed, thermodynamically constrained model of the cross-bridge cycle provides additional insight into this conclusion. Copyright © 2010 the American Physiological Society.
AB - We trace the history of attempts to determine whether the experimentally observed diminution of metabolic energy expenditure when muscles lengthen during active contraction is consistent with reversibility of biochemical reactions and, in particular, with the regeneration of ATP. We note that this scientific endeavor has something of a parallel flavor to it, with both early and more recent experiments exploiting both isolated muscle preparations and exercising human subjects. In tracing this history from the late 19th century to the present, it becomes clear that energy can be (at least transiently) stored in a muscle undergoing an eccentric contraction but that this is unlikely to be due to the regeneration of ATP. A recently developed, thermodynamically constrained model of the cross-bridge cycle provides additional insight into this conclusion. Copyright © 2010 the American Physiological Society.
UR - http://hdl.handle.net/10754/600194
UR - https://www.physiology.org/doi/10.1152/japplphysiol.01198.2009
UR - http://www.scopus.com/inward/record.url?scp=77953169003&partnerID=8YFLogxK
U2 - 10.1152/japplphysiol.01198.2009
DO - 10.1152/japplphysiol.01198.2009
M3 - Article
C2 - 20133436
SN - 8750-7587
VL - 108
SP - 1465
EP - 1471
JO - Journal of Applied Physiology
JF - Journal of Applied Physiology
IS - 6
ER -