ZnCo2O4 Nanoflowers Grown on Co3O4 Nanowire-Decorated Cu Foams for in Situ Profiling of H2O2 in Live Cells and Biological Media

Veerappan Mani, Shanthi Selvaraj, Tie Kun Peng, Hsin Yi Lin, Nithiya Jeromiyas, Hiroya Ikeda, Yasuhiro Hayakawa, Suru Ponnusamy, Chellamuthu Muthamizhchelvan, Sheng Tung Huang

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

A robust real-time quantification method is essential to understand the physiological roles of endogenous H2O2 in biological systems. For this purpose, we described a binary transition-metal oxide (TMO)-based nanointerface, i.e., spinal zinc cobaltite/cobalt oxide ternary nanoarrays (ZnCo2O4/Co3O4) on a Cu foam (CF). The ZnCo2O4/Co3O4/CF facilitates H2O2 reduction at a minimized overpotential (-0.10 V vs Ag/AgCl). which is several millivolts away from the voltammetric regions of common biological and oxygen interferences, making the electrode highly selective in the presence of 5-fold excess concentrations of biological species. In the presence of ZnCo2O4, the electrocatalytic capability of Co3O4 has increased significantly by enlarging the electrochemical active area of the electrode (0.538 cm2). A substantial improvement in the stability (97.24%) and reproducibility (relative standard deviation = 3.14%) are attained because the direct growth of nanomaterials is generated on CF in close proximity with the electrode surface and strengthens the affinity. The modified electrode endows ultrasensitivity (detection limit = 1 nM) and quantifies the amount of H2O2 released from mammalian cells (8.7 × 10-14 mol). Binary TMOs hold promise in tailoring a reliable H2O2-detecting interface for real-time, in vivo applications.
Original languageEnglish (US)
Pages (from-to)5049-5060
Number of pages12
JournalACS Applied Nano Materials
Volume2
Issue number8
DOIs
StatePublished - Aug 23 2019
Externally publishedYes

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