Intrinsic connectivity networks (ICNs) refer to brain functional networks that are consistently found under various conditions, during tasks or at rest. Some studies demonstrated that while some stimuli do not impact intrinsic connectivity, other stimuli actually activate intrinsic connectivity through suppression, excitation, moderation or modi cation. Most analyses of functional magnetic resonance imaging (fMRI) data use ad-hoc methods to estimate the latent structure of ICNs. Modeling the effects on ICNs has also not been fully investigated. Bayesian Intrinsic Connectivity Network (BICNet) captures the ICN structure with We propose a BICNet model, an extended Bayesian dynamic sparse latent factor model, to identify the ICNs and quantify task-related effects on the ICNs. BICNet has the following advantages: (1) It simultaneously identifies the individual and group-level ICNs; (2) It robustly identifies ICNs by jointly modeling resting-state fMRI (rfMRI) and task-related fMRI (tfMRI); (3) Compared to independent component analysis (ICA)-based methods, it can quantify the difference of ICNs amplitudes across different states; (4) The sparsity of ICNs automatically performs feature selection, instead of ad-hoc thresholding. We apply BICNet to the rfMRI and language tfMRI data from the Human Connectome Project (HCP) and identify several ICNs related to distinct language processing functions.
| Date of Award | Nov 25 2020 |
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| Original language | English (US) |
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| Awarding Institution | - Computer, Electrical and Mathematical Sciences and Engineering
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| Supervisor | Hernando Ombao (Supervisor) |
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- fMRI
- Dynamic Functional Connectivity
- Intrinsic Connectivity Network
- Stochastic Volatility
- Bayesian Hierarchical Model
- Dynamic Latent Factor Model